Center Drive, 7th Floor
Newport Beach, California 92660
Amit Kumar, Ph.D.,
Chief Executive Officer And President
Brooke Anderson, Ph.D.
Chief Operating Officer
Jeffrey Oster, Ph.D.,
Senior Vice President, Intellectual Property
Scott Burell, CPA, Vice President Finance
H. Sho Fuji, Vice President
Engineering and Production
Acacia offers biochips
through its subsidiary, CombiMatrix Group. CombiMattix has developed a system to create custom biochips used for the identification
and function of genes, gene mutations and proteins. Combimatrix produces the oligonucleotide microarray, which its customers
design. Combimatix's semiconductor-based in situ synthesis platform is used to build custom microarrays. Applications for
the company's technology include DNA synthesis and diagnostics, and immochemical detection.
(LOC) core technology is used to digitally control the molecular assembly of biopolymers. The LOC integrated circuit consists
of an array of microelectrodes that are individually addressable through digital logic located on the chip. The chip interacts
with a fluidic chamber. When a microelectrode is addressed a specific chemical
reagent is produced via an electrochemical reaction. The chemical reagents than can be used in the synthesis of DNA oligonucleotides
or other complex molecules. The CombiMatrix chip can be used to synthesize over a thousand different molecules in parallel
- proportional to the number of electrodes. A unique chemical reagent is generated, under control of the digital logic circuitry,
at each site. A unique aspect of the chip is that it permits synthesis of different molecules with one chip. The electrodes
in one chip measure 94 microns in diameter.
In September of 2004 Intel Corp., one of the world’s largest semiconductor
companies, entered into a confidential agreement with CombiMatrix.